Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation

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Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation

Epidemiologic studies suggest that dietary polyphenol intake is associated with a lower incidence of several non-communicable diseases.

Although several foods contain complex mixtures of polyphenols, numerous factors can a ect their content. Besides the well-known capability of these molecules to act as antioxidants, they are able to interact with cell-signaling pathways, modulating gene expression, influencing the activity of transcription factors, and modulating microRNAs. Here we deeply describe four polyphenols used as nutritional supplements: quercetin, resveratrol, epigallocatechin gallate (ECGC), and curcumin, summarizing the current knowledge
about them, spanning from dietary sources to the epigenetic capabilities of these compounds on microRNA modulation.

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